Beginner's Mind

Christian Soschner

"Beginner's Mind with Christian Soschner" is your lens into entrepreneurship and investing in deep tech - the frontier of AI, biotech, blockchain, robotics, and more.

The podcast features Christian Soschner engaging in insightful conversations with innovators, entrepreneurs, investors, and thought leaders who are crafting the blueprint of our future.

Here's what you can expect:

  • In Episode 111, Colin McCann sheds light on transformative vaccine strategies at IVI.
  • Episode MM4 takes you on Nanotemper's journey from science fiction to microgravity with Philipp Baaske.
  • Episode MM3 features Jeevan Sunner discussing the ascent of female leaders in tech and venture capital.


The episodes dissect these pioneers' journeys, offering listeners valuable lessons.

In addition to these insightful conversations, I also continuously unearth gems of wisdom from renowned entrepreneurs and investors like Warren Buffett, Jeff Bezos, Elon Musk, and Mohnish Pabrai. These insights and my commentary aim to help decipher the complex world of investing and entrepreneurship, providing you with actionable knowledge and strategies.

Topics range from AI's role in drug discovery to the intricate science behind pharmaceutical research, offering a comprehensive deep tech entrepreneurship and investing education enriched by practical insights from industry frontrunners.

Embark on this  journey.

Be part of the conversation shaping the future of technology. The Podcast Community welcomes you: https://lsg2g.substack.com/

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#112: BIO's Rich Masters on the Future of Biotech and the International Convention
2d ago
#112: BIO's Rich Masters on the Future of Biotech and the International Convention
Navigating the biotech industry's rapid advancements and complex regulations can be daunting. High-stakes investments and the pressure to innovate further add to the challenge.Rich Masters, the CMO of BIO (Biotechnology Innovation Organization), is a seasoned expert in this field. His role in organizing the BIO International Convention and his extensive industry experience equips him with unique insights to tackle these challenges.In this fantastic podcast episode, we delve into:🔬 The behind-the-scenes experience of organizing and attending the BIO International Convention 2022 in San Diego.🔬 Rich's journey to the helm of BIO as CMO and his vision for the organization.🔬 The meticulous preparations for the upcoming BIO International Convention 2023 in Boston, anticipated to be a landmark event in the biotech calendar.🔬 The innovative features and services introduced for the BIO International Convention 2023, including the BIO Podcast series and the BIO News platform.🔬 Rich's perspective on the future of the biotech industry, discussing potential challenges and opportunities for 2024 and beyond.💡 LINKS TO MORE CONTENTYoutubeChristian Soschner:Rich Masters📖 Memorable Quotes:(13:50) "The majority of biomedical and drug innovation investments fail... This ecosystem is crucial and needs protection."(15:00) "Developing a drug is an expensive process... Without investment, the engine of innovation stalls, we don't see new drugs on the market."(16:38) "If you price fix these drugs, you are going to stop the cures of the future."(20:01) "What we're witnessing worldwide is an attack from socialist-minded groups against intellectual property, our only asset."(26:18)"Our main focus may be on Washington, but we work closely with our International Biotech Association based in Brussels. We have numerous international partners."(29:09) "As the next pandemic looms, the question is, do we want all drug development concentrated in one country, or a viable drug development market in the West?"(42:12) "We can't continue to stifle innovation and science and then expect to create the next generation of cures... we're eliminating entire classes of diseases."(44:10) "Biotechnology provides the solution for eliminating food insecurity, transitioning from fossil fuels to green energy sources, and ending disease... we need to establish policies that encourage, rather than stifle, innovation."⏰ Timestamps:(03:45) - [Recap: BIO Convention Collaboration Success](05:18) - [BIO Event Excellence: Future Planning Insights]The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
SP8: The Art of Successful Investing: Lessons from Mohnish Pabrai
1w ago
SP8: The Art of Successful Investing: Lessons from Mohnish Pabrai
Navigating the investment landscape can be a daunting task. It's easy to feel like you're constantly making the wrong moves and not achieving your financial goals. This episode brings you the wisdom of legendary investor Mohnish Pabrai, who shares his insights on overcoming these hurdles and achieving success in investing.Here's what you can expect from this episode:Understanding Cognitive Biases Time Marker: (01:44): Our brains, evolved over millennia, are not naturally wired for investing. Mohnish Pabrai explains how understanding our cognitive biases can help us become better investors.The Importance of Patience Time Marker: (03:28): Successful investing requires a long-term approach and a willingness to hold on to great businesses. Pabrai shares his thoughts on why patience is a virtue in investment.Lifelong Learning Time Marker: (05:04): The investment landscape constantly changes. Pabrai emphasizes the significance of continual learning in staying ahead in the investing game.By the end of this episode, you'll better understand how to navigate the investment landscape and make more informed decisions. So, tune in, take notes, and let's embark on this journey to financial growth together.Don't forget to share this episode with your friends and colleagues who might find it useful. And if you enjoyed this episode, please leave us a review. Your feedback helps us improve and reach more people like you.YoutubeSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#111: Colin McCann Reveals Game-Changing Vaccine Strategies at IVI
May 10 2023
#111: Colin McCann Reveals Game-Changing Vaccine Strategies at IVI
Are you tired of seeing the world struggle with global health crises? It's a harsh reality that many vaccine-preventable diseases continue to devastate vulnerable populations. But there's hope on the horizon!In this eye-opening episode, we dive deep into a conversation with Colin McCann, a key player at the International Vaccine Institute (IVI), who shares incredible insights into their innovative approach to combatting these health challenges. You'll discover the groundbreaking strategies and collaborative efforts reshaping how we develop and deliver life-saving vaccines to those who need them most.Don't miss out on this unique opportunity to learn about the future of global health and how the IVI is making a real difference. Click now to watch the full episode and get inspired!💡 LINKS TO MORE CONTENTYoutubeChristian Soschner: Colin McCann📖 Memorable Quotes:(29:30) "IVI's role is to pick up challenges that the pharma industry would turn down, starting with comprehensive disease burden studies and surveillance to determine the true burden of neglected diseases."(40:02) "There's the great problem of the translational graveyard - we have lots of wonderful vaccine candidates sitting on shelves around the world collecting dust, instead of saving lives."(41:47) "European developers should realize that they could manufacture their vaccines in Africa, Latin America, or Asia and maintain profitability in doing so."(55:51) "Countries that are often in tension with each other are able to cooperate on vaccine development."(01:01:46) "By linking low & middle income countries together, they can train each other and build upon each other's abilities."(01:18:44) "IVI's proven model: developing a vaccine from evidence through licensure & delivery, takes a comprehensive approach."⏰ Timestamps:(02:28) Vienna: The Hub for IVI's European Expansion(07:55) The Unconventional Path to Joining the International Vaccine Institute(11:09) Colin's journey: From wind turbine engineer to IVI member(17:51) Bridging the gaps in vaccine development and scaling(21:47) IVI's role in growing South Korea's biotech sector(28:31) IVI's Role in Addressing Unmet Vaccine Needs(35:56) Exploring IVI's Role in Clinical Development and Vaccine Manufacturing(38:31) Facilitating Industry Partnerships and Filling Global Health Gaps(42:42) Attracting Private Investors and Venture Capital in Vaccine Development(45:50) The Role of CEPI in Addressing the Funding Gap for Vaccine Development(49:35) ASEAN: Coordinating Vaccine DevelThe Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
MM4: Philipp Baaske - From Science Fiction to Microgravity: Nanotemper's Journey to the International Space Station
Apr 26 2023
MM4: Philipp Baaske - From Science Fiction to Microgravity: Nanotemper's Journey to the International Space Station
Discover the groundbreaking journey of Nanotemper Technologies as CEO Philipp Baaske shares his passion for space exploration, science fiction, and the company's ambitious project aboard the International Space Station. Learn how microgravity is poised to revolutionize biotech research and redefine our understanding of protein stability. Don't miss this exclusive conversation with one of the most innovative minds in the industry!Quote:(02:44) "To really understand what temperature alone does to [antibodies] without flows, you have to switch off gravity, which you can't do on Earth. But on the International Space Station, with microgravity, there's nearly no influence of gravity, so we can study the stability of antibodies without the influence of gravity or thermal convective flows."⏰ Timestamps(00:44) Passion for Space Exploration: Star Trek, Star Wars, and SpaceX(03:25) Organizing a Space Project: Collaboration and Opportunities(05:16) Pursuing Exciting Projects for Fun and Scientific Advancement(06:39) Inspirations from Science Fiction: Isaac Asimov's Lucky StarWatch the full video: 💡 LINKS TO MORE CONTENTPodcast: https://beginnersmind.buzzsprout.com/779930/12585340Philipp Baaske: https://www.linkedin.com/in/philipp-baaske/Christian Soschner: https://www.linkedin.com/in/christiansoschner/#nanotemper #spaceexploration #microgravity #philippbaaskeSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
MM3: Jeevan Sunner - Powerful Voices: The Rise of Female Leaders in Tech and Venture Capital
Apr 10 2023
MM3: Jeevan Sunner - Powerful Voices: The Rise of Female Leaders in Tech and Venture Capital
In this captivating episode of our podcast, we address the pressing issue of gender diversity within the tech and venture capital sectors, inviting Jeevan Sunner, a distinguished investor from Playfair Capital, to share her invaluable insights on the matter. Jeevan emphasizes the importance of promoting female representation in the industry and explores the vast opportunities that can arise from embracing diverse perspectives.As CEOs and investors, understanding the immense value of nurturing a more inclusive environment is essential to unlock the full potential of the tech sector and maximizing investment returns. This episode sheds light on the challenges faced by women in tech and venture capital and discusses the actions that can be taken to create a more equitable landscape.Tune in to this enthralling conversation and learn how your organization can foster change and benefit from increased diversity in the tech and venture capital fields. Don't miss this chance to listen to a leader who is spearheading the movement for inclusivity and championing the transformative power of gender equality in the tech world.Subscribe to our podcast and stay informed on the latest trends and insights that will help you navigate the ever-evolving landscape of the tech and venture capital industries.Link to full episode⏰ Timestamps(00:00) Intro(01:00) Jeevan Sunner talks about the Gender GAP in the Startup World 💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribeWatch on YoutubeJeevan SunnerChristian SoschnerSupport the showSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#110: DC Palter - From Japan to Silicon Valley: A Unique Business Angel Journey
Apr 6 2023
#110: DC Palter - From Japan to Silicon Valley: A Unique Business Angel Journey
Unlock the secrets to startup success! Dive into an engaging conversation with DC Palter, a seasoned startup founder, CEO, and angel investor, as he shares invaluable insights and advice for CEOs and investors. Explore resilience, Japanese culture's impact on business, and innovative strategies. Don't miss out!💡 LINKS TO MORE CONTENTCheck out our partnersYoutubeChristian SoschnerToday’s speaker is DC Palter 📚 Book mentions in the episode:To Kill a Unicorn The Power Law 📖 Memorable Quotes:(14:42) "We need to think outside the box, have a goal, a dream; sometimes it works out spectacularly, and a lot of times it doesn't, but we tried and that's the building blocks for the next one."(42:23) "The number that's always quoted is “90% will fail”, but that doesn't mean fail outright. That means not succeeding as expected. About half of those will actually fail outright and give you no return, and then another four will give you something like your money back, maybe a little bit more, maybe a little bit less. So we call that a failure anyway, even though they haven't really completely failed."(01:01:56) "You can have a really simple idea, but if you have a lot of customers for it, if you know how to market it and build up a brand name, you can make a lot of money – and that's what investors are looking for."(1:27:57) "Marketing is about understanding the business, the market, and the customers, and becoming part of that community, so that customers find you."(1:48:07) “Embrace resilience, for every day is a challenge. You may be familiar with the English expression, 'three steps forward, two steps back.' However, in the world of startups, it's more like taking three steps forward and 2.9 steps back. Indeed, each day is a roller coaster ride.”⏰ Timestamps:(01:46) Tea Ceremony, Japanese Culture, and Shared Interests(05:15) Who is Satoshi Nakamoto?(06:39) Silicon Valley Life, Work, and Writing Experience(07:22) Arnold Schwarzenegger and the Startup World(13:00) Tesla's Success: Overcoming Skepticism in Electric Vehicles (16:21) Theranos: Fake it Till You Make It(20:04) The Valley of Death: Challenges in Raising Money for Hard Tech Startups(24:42) Defining Financial The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifyThe LSG2G Partners Experts in Life ScienceDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#109: Philipp Baaske's Journey: From Small Village to Biotech Entrepreneur
Apr 4 2023
#109: Philipp Baaske's Journey: From Small Village to Biotech Entrepreneur
Join us in this episode as we talk to Philipp Baaske, CEO of Nanotemper, and explore the ins and outs of building a successful biotech startup. We cover topics such as bootstrapping, finding customers, developing effective leadership skills, and more. Gain valuable insights and advice from Philipp's experiences as a business angel and entrepreneur. Tune in to learn how to build and scale a successful biotech startup.💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePhilipp BaaskeChristian Soschner📖 Memorable quotes:(36:18) "First of all, I disagree with Steve Jobs, it's important to talk with customers about their problems, but it's really about the problem, not talking about a technical solution." (48:17) "If you don't fail, you do something wrong because if it always works, you don't do the risky thing; you just do the easiest thing."(01:10:20) "This is my advice on startups: sell. Sell a product before you have it because if the customer gives you money for it, you know that it's worth developing it."(01:12:39) "We never thought about failing. Failure was not in our mind." (01:19:31) “I strongly believe that every disease is treatable.”⏰  Timestamps:(00:00) Introduction(02:30) The Impact of SVP Bankruptcy on Entrepreneurship(06:41) The Importance of Proper Risk Management(09:51) Absolute Focus on the Things You Can Influence(12:05) Managing a Global Team: Trust, diversity, and decentralized decision-making (14:56) Trusting the Best People(17:01) Hiring with Gut Feeling and CV-Application Letter Match(20:32) Marketing and Cultural Diversity(28:43) The Importance of Product-Market Fit Over Funding and Investors(29:12) Finding Customers vs Finding Investors(33:43) Milestones and Helping Customers(38:00) Talking to Customers About Their Problems(40:06) Identifying Markets and Competitors(42:56) Unlocking New Cancer Treatment Pathways(45:26) Overcoming Failure in Startups and Drug Discovery(48:49) Breaking Out of Confinement and Pursuing Goals(56:37) Impact of Upbringing on Entrepreneurial Spirit(57:33) Stop complaining, start improving: lessons from Vienna(01:00:04) Curiosity-driven education: finding a passion for physics(01:03:21) Experimenting in microgravity: sending projects to the ISS(01:14:20) Startup advice: focus on sales and steady growth(01:12:39) Overcoming adversity: believing in our technology(01:15:31) The potential of every disease being treatableThe Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
MM 2: The Shocking Truth Behind Declining Drug R&D Productivity with Dr. Jack Scannell
Mar 27 2023
MM 2: The Shocking Truth Behind Declining Drug R&D Productivity with Dr. Jack Scannell
In today's episode, we uncover the hidden crisis in the pharmaceutical industry as we explore the alarming state of R&D productivity. Our guest, Dr. Jack Scannell, is a renowned scientist and entrepreneur with extensive experience in both the biotech and investment fields. He shares his valuable insights into the concept of Eroom's Law, which reveals the inverse relationship between input efficiency and output efficiency in drug research and development.Listen in as we discuss the challenges of measuring R&D productivity and how financial return and number of drugs approved per unit input serve as key indicators of productivity. Dr. Scannell helps us understand the reasons behind the decline in R&D productivity since the 1950s and the factors that have contributed the most to this concerning trend.Don't miss this enlightening conversation that exposes the harsh reality of pharmaceutical R&D productivity, and be sure to share your thoughts and opinions by leaving a review or engaging with us on social media. We'd love to hear from you!Stay informed on the latest developments in pharmaceutical R&D productivity and other pressing global challenges by subscribing to our podcast. Your support helps us continue to bring you thought-provoking discussions and expert insights.Link to full episode⏰ Timestamps00:00 Intro01:00 Jack Scannell Explains Eroom's Law💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribeWatch on YoutubeJack ScannellChristian SoschnerSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
MM 1: Alex Zhavoronkov - Transforming Drug Discovery Forever: How AI Is Revolutionizing Medicine and Changing Lives!
Mar 9 2023
MM 1: Alex Zhavoronkov - Transforming Drug Discovery Forever: How AI Is Revolutionizing Medicine and Changing Lives!
Welcome to our new series, Memorable Moments! In this series, we bring you highlights from past episodes that contain some of the most memorable insights and important information that you won't want to miss. In this episode, we explore the groundbreaking potential of AI in drug discovery and anti-aging research. Listen in as we share clips from our interview with Alex Zhavoronkov, who is leading the charge in this revolutionary technology that cuts costs, increases success rates, and drastically shortens the time it takes to develop new therapies. Join us as we share memorable moments and life-changing insights that will help you discover the incredible potential of the future of medicine. Don't miss out on this powerful and inspiring episode of our podcast - tune in now!Listen to the full episode ⏰ Timestamps00:00 Intro00:44 Alex Zhavoronkov Explains how his solution increases the probability of success, cuts costs and timelines in Drug Discovery and Development07:20 Shout out to our new subscribers on Buzzsprout+💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribeWatch on YoutubeAlex ZhavoronkovChristian SoschnerCheck out the organizations that make the podcast possibleSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#108: Alex Zhavoronkov - Revolutionizing Medicine: How AI Will Cure Aging
Mar 6 2023
#108: Alex Zhavoronkov - Revolutionizing Medicine: How AI Will Cure Aging
Are you ready to dive into the future of medicine and the revolutionary advancements being made with artificial intelligence? In this episode, I sit down with Alex Zhavoronkov, the founder and CEO of Insilico Medicine, a global company focused on the discovery of novel therapeutics utilizing cutting-edge technology in healthcare.From longevity research to anti-aging treatments, Alex shares his expertise on themost impactful field of our time, discussing his work in protein targetdiscovery and the design of small molecule drugs using generative AI.But it doesn't stop there. Alex also shares insights into the development of agingclocks, biomarkers of aging, and precision medicine. Discover how generative AIis transforming the pharmaceutical industry, improving clinical trials, andproviding a revolutionary new approach to drug discovery methods.Don't miss out on this incredible opportunity to learn from one of the leadingexperts in AI and healthcare innovation. Tune in now and join us on thisfascinating journey into the future of medicine.💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribeWatch on YoutubeAlex ZhavoronkovChristian SoschnerCheck out the organizations that make the podcast possible📖 Memorable quotes:(10:50) “Insilico Medicine synthesized and tested the first AI generated drug in 2017.”(23:09) “Generative AI in Drug Discovery and Drug Development has the potential to improve the probability of success by 50%”(24:00) “Generating 11 preclinical candidates in 2.5 years - is a pretty cool number.”(29:48) “We developed a clinical candidate in 18 months at a 3 million dollar cost with the help of AI. The traditional route takes 2 years at about 400 million expeonses.”(01:08:48) “Generative AI will transform our lives beyond recognition in every way.”⏰  Timestamps:(02:00) Introduction to Alex Zhavoronkov at World Government Summit 2023 (03:00) About World Government Summit 2023 (04:20) Alex's longevity research at Insilico Medicine (08:20) Accelerating drug discovery with AI (13:00) AI in synthetic biologic data (15:00) Generative AI in reducing cost and increasing output (23:30) Generative AI in increasing probability of success (25:00) Why traditional drug R&D takes over 10 years and 2 billion 2010 dollars (28:45) AI-driven drug discovery at Insilico Medicine The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
SP 5: Unleashing Your Creative Potential: Sol LeWitt's Timeless Advice to Eva Hesse
Feb 25 2023
SP 5: Unleashing Your Creative Potential: Sol LeWitt's Timeless Advice to Eva Hesse
Are you struggling with your creative process? Do you feel stuck in a rut or blocked by perfectionism? You're not alone. In this episode, I explore the remarkable letter from artist Sol LeWitt to Eva Hesse, which has inspired creatives for decades.Not only creatives can get stuck and blocked. Also, entrepreneurs, scientists, and investors can have to face such situations in their lives. Read by Benedict Cumberbatch for Letters Live at the Freemason's Hall in London, LeWitt's timeless advice urges us to stop overthinking and DO. Embrace the process, let go of perfectionism, and believe in your ability to create. Join me as I discover the wisdom of emptiness and how it can help you unleash your full potential. From conceptual art to minimalism, I delve into the fascinating lives of Sol LeWitt and Eva Hesse, two American artists who embarked on a supportive friendship that would inspire them both. So sit back, relax, and let's listen to the words of Sol LeWitt as read by Benedict Cumberbatch. This episode is a must-listen for anyone looking to break free from creative blocks and unleash their full potential.⏰ Timestamps(00:00) Unleashing Your Creative Potential: The Remarkable Letter from Sol LeWitt to Eva Hesse Read by Benedict Cumberbatch(01:15) Background Information to Sol LeWitt, Eva Hesse, and their Inspiring Correspondence(04:00) Sol LeWitt's Timeless Advice to Eva Hesse: Stop Overthinking and Just DO(06:25) Perfectionism Kills Creativity(08:57) Embrace the Process, Don’t Focus on the Outcome(10:09) Believe in your ability to create💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Check out our partners: https://linktr.ee/lsg2Watch on YoutubeChristian SoschnerSupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#107: Jack Scannell - Uncovering Drug Development Efficiency Secrets: The Science Behind Pharmaceutical Research
Feb 19 2023
#107: Jack Scannell - Uncovering Drug Development Efficiency Secrets: The Science Behind Pharmaceutical Research
Do you ever wonder why it takes so long for new drugs to hit the market? Have you ever questioned the efficiency of the pharmaceutical industry?Join me in this episode as we talk to Jack Scannell, a pharmaceutical industry expert, and discover the hidden efficiency secrets of drug development. In this episode, we delve into the critical factors that have shaped drug development over the last 60 years and analyze the industry's current state.Throughout the podcast, Jack draws on his extensive industry knowledge and provides insights on the importance of decision quality, the role of AI in drug discovery, and the economics of the research model.If you're looking to gain a better understanding of the pharmaceutical industry and its inner workings, join us in uncovering the efficiency secrets of drug development. Tune in to this episode.💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribeWatch on YoutubeJack ScannellChristian Soschner📖 Memorable quotes:(11:41) “Between 1950 and 2010, Drug Development saw a halving time: Every nine years, the number of drugs developed per billion dollars spent halved.”(24:58) “4 Reasons for the Decline of Drug Development Productivity: Better Than the Beatles Problem, Higher Regulatory Hurdles, Throw Money at it Problem, Misindustrialisation of Science(26:30) “Metformin is the Pharmaceutical Equivalent to the Beatles”(45:15) “In early drug discovery, predictive validity, the degree to which your model output correlates with human clinical utility is critically important”(01:19:31) “If the only tool you have to measure the height of the fruit is the rate at which you are picking fruit, and you notice that the rate of picking fruit is declining, you will always blame the low hanging fruit problem.”(01:34:15) “When capital is freely available, the average quality is going down”⏰  Timestamps:(00:00) Introduction: Uncovering Drug Development Efficiency Secrets(06:30) Background Jack Scannell: Pharma Journey(09:15) Finding erooM’s Law: Playful Experiment Leads to Discovery(12:00) Inversion of Output Efficiency: More Capital, Fewer Drugs(13:15) Best Key Figure for R&D Productivity?(20:24) Factors Behind R&D Productivity Decline - 1950 to 2010(25:30) The Beatles Inform Drug Development(28:34) The Regulatory Problem(30:00) Throwing Money at the Problem & Misindustrialisation of Science(31:00) Turnaround in Drug Development EfficiencyThe Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#106: Breaking Barriers: Jeevan Sunner's Journey as a Female VC
Jan 30 2023
#106: Breaking Barriers: Jeevan Sunner's Journey as a Female VC
Are you curious about what it takes to be a female venture capitalist in 2023? Join us as we sit down with Jeevan, a successful woman in the industry, to discuss the world of female entrepreneurship and venture capitalism. With her insights on the tech focus areas of 2023, the challenges of attracting women into the VC world, and the importance of warm referrals, Jeevan offers a unique perspective on the startup investment landscape. Get a glimpse into the life of a female VC as she shares her journey and valuable lessons learned. Tune in now to learn what it takes to become a venture capitalist in 2023 and expand your knowledge on the exciting world of startup investments.💡 LINKS TO MORE CONTENTIf you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Check out our partners: https://linktr.ee/lsg2Watch on YoutubeJeevan SunnerChristian Soschner📖 Memorable quotes:(49:33) “Linkedin Made Investors in Silicon Valley Accessible”(49:55) “Communication, Accessibility, Relationship building, and Information sharing make social media super powerful.”(55:40) “Take your time and do your due diligence on investors to understand whether their values are aligned with yours and whether you see that 10-15 years partnership happening.”(59:30) “We are flexible in the way we collaborate with founders. It can be a more passive approach, or for first-time founders more hands-on”(01:09:00) “When it comes to dilution, we rather have a smaller slice of a bigger pie, than a massive slice of a smaller pie” ⏰  Timestamps:(00:00) Unlocking the Secrets of Venture Capital: An Insider's View (03:15) Brave the Winter of England with Jeevan in December 2022 (05:44) The Journey to Becoming a Top Venture Capitalist in 2023 (11:00) Spotting the Next Big Tech Trend in 2023 (14:20) Empowering Female Entrepreneurs and VCs to Create Change (20:00) Breaking Barriers: What it Takes to Attract More Women in Tech VC (23:00) The Power of Warm Referrals and How VCs Evaluate a Pitch deck (26:00) Timing is Everything: When is the Right Moment to Approach a VC? (30:30) A Day in the Life of a Busy Venture Capitalist (39:30) Decoding Job Titles in Venture Funds: What They Really Mean (44:15) The Human Side of Investing: Why Relationships are Key (46:15) 2 Vital Lessons for Founders from a VC's Perspective The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   Spotify The First CustomerWant to start or grow your business? Learn how founders got their first customer.Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#105: Expert Insights on Biophysics and the Future of Drug Discovery: An Interview with Dr. Thomas Schubert of 2bind
Jan 23 2023
#105: Expert Insights on Biophysics and the Future of Drug Discovery: An Interview with Dr. Thomas Schubert of 2bind
Are you ready for the grand finale of our Year in Review Recording? The final episode of 2022 is here, and it's one for the books! We've explored the cutting-edge innovations and technologies shaping the future of the biotech industry with some of the most brilliant minds in the field. From Kurt Höller of EIT Health, to Albert Missbichler from Fianostics, Caroline Heil from the new meat company, Mauricio Agudelo and Lina Toro from Bialtec, Kimberly Cornfield from the UCL, Collin Ewald from ETH Zurich, and Guido Gualdoni from G.ST Antiviral, we've had some truly enlightening conversations. But we saved the best for last! Get ready for an exclusive interview with Dr. Thomas Schubert, CEO of 2bind, a provider of biophysical outsourcing solutions that is revolutionizing the way we study molecular interactions and protein stability. Don't miss out on this one-of-a-kind episode. Tune in now! This cutting-edge biotech company is revolutionizing how we study molecular interactions and protein stability. They're doing it with a track record of over 1400 successfully completed tasks in research projects with over 350 customers in the last 11 years.In this episode, you'll get an inside look at the driving force behind 2bind and the expert knowledge that sets them apart in the biophysics field. From breakthrough moments to industry trends, you'll gain a deeper understanding of the future of biotech and the role that companies like 2bind will play in shaping it.But that's not all! You'll also hear from Dr. Schubert about the company's partnerships with leading device producers and how they navigate the digital world to stay ahead of the curve. Plus, you'll get insight into the supply chain challenges that 2bind faced in the last years and how they overcame them.Don't miss out on this opportunity to learn from the best in the business! Tune in to our latest podcast episode and join the conversation on the future of biotech.Trust us; this episode is a must-listen for anyone in the biotech industry or anyone passionate about innovation and the future of medicine. It's packed with valuable insights and information you won't miss.💡 LINKS TO MORE CONTENT.If you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Check out our partners: https://linktr.ee/lsg2Watch on YoutubeThomas SchubertChristian Soschner⏰  Timestamps:00:00) Introduction(02:00) Unveiling the mastermind behind 2bind, Dr. Thomas Schubert (04:05) Insider tips for starting your own biotech company(07:36) A glimpse into the future: 2022 for 2bind's CEO (10:40) Navigating the digital world: Pros and cons of technology in biotech (14:16) Overcoming obstacThe Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#104: Revolutionizing Respiratory Antivirals: The Science behind G.ST Antivirals
Jan 22 2023
#104: Revolutionizing Respiratory Antivirals: The Science behind G.ST Antivirals
On this episode of "Year in Review Recording," we speak with Guido Gualdoni, Co-Founder, and CEO of G.ST Antivirals, a clinical-stage biotech company revolutionizing how we treat viral infections of the respiratory tract. Guido shares the science behind G.ST Antivirals' innovative host cell-based strategy to develop broad-spectrum antivirals and how it completely eliminates viral reproduction without the risk of resistance development. He also delves into the public funding and startup ecosystem in Vienna, Austria, which has been instrumental in the company's success. He also talks about the future plans for G.ST Antivirals and the deep scientific tech valley in Central Europe. This episode is a must-listen for anyone interested in the latest advancements in biotech and the companies leading the way in treating viral infections. 💡 LINKS TO MORE CONTENT.If you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Please support this show by checking out the companies that make it possible: https://linktr.ee/lsg2Watch on YoutubeGuido GualdoniChristian Soschner⏰  Timestamps:(00:00) Welcome to the Episode: Exploring the Public Funding and Eco-System in Vienna, Austria(02:35) Meet Guido Gualdoni, CEO of G.ST Antiviral(04:00) Discovering the StartUp Labs, Vienna Business Agency, AWS, FFG, Austrian Business Agency, LISA Vienna and their role in supporting startups(07:35) Exploring the Scientific Deep Tech Valley in Central Europe: Munich, Vienna, Zurich, Prague(10:15) G.ST Antiviral's 2022 Outlook(11:22) Uncovering the Innovative Technology Behind G.ST Antiviral(14:30) Guido's Biggest Takeaways from 2022(16:15) Why Optimism Bias Can be a Challenge for Entrepreneurs(18:15) Comparing the Scientific and Entrepreneurial Mindsets(24:00) The Surprising Companies that Succeeded During Economic Downturns(25:00) Examining the Latest Trends in Antiinfectious Diseases(27:45) Charting the Growth of G.ST Antiviral in 2023The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#103: The Future of Aging Research: Insights from the Founder of the Swiss Society for Aging Research, Dr. Collin Y. Ewald
Jan 19 2023
#103: The Future of Aging Research: Insights from the Founder of the Swiss Society for Aging Research, Dr. Collin Y. Ewald
Introducing "The Year in Review Recordings", a series where we reflect on the past year and look forward to the coming one. Hosted by Christian Soschner, this podcast brings you expert speakers from previous episodes and partners of the podcast to give you an in-depth analysis of the latest advancements in their fields and an outlook for the future. This is the 6th conversation in the series.In this episode, we have Dr. Collin Y. Ewald, founder and president of the Swiss Society for Aging Research and head of the Extracellular Matrix Regeneration Laboratory at the Department of Health Sciences and Technology. Dr. Ewald has a longstanding interest in the molecular biology of healthy aging and age-related pathologies. He is a leading expert in the field and has received multiple awards, including NYAS Future Entrepreneur, recognized by the New York Academy of Sciences. He is named among the top 1000 Longevity Leaders worldwide and the top 15 Longevity Influencers in Switzerland.We'll be discussing Dr. Ewald's recent work on the expression of extracellular matrix genes during aging, the role of the mTOR kinase in aging, and the challenges of bridging gaps in longevity research between scientific disciplines and languages. We'll also be discussing the Ewald Lab's recent work on the expression of extracellular matrix genes during aging, the role of the mTOR kinase in aging, and the challenges of bridging gaps in longevity research between scientific disciplines and languages.This episode also includes topics such as Longevity Research and Horizon Europe, How to Bridge the Gap in Horizon Programs between scientific disciplines and different languages, The 9 Hallmarks of Ageing, Solving the Clinical Trial Challenges in Longevity Research, Food Supplements for Longevity in 2023, Collin Ewald’s Spin Out Company, The 10 Simple Rules to Start a Successful Spin-Off Company, 2023 in Longevity Research – Upcoming Trends.Don't miss out on this episode of "The Year in Review Recordings," where we dive into the world of longevity research with Dr. Collin Y. Ewald and stay informed about the latest advancements in the field.💡 LINKS TO MORE CONTENT.If you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Please support this show by checking out the companies that make it possible: https://linktr.ee/lsg2Watch on YoutubeCollin EwaldChristian Soschner⏰  Timestamps:(00:00) Intro (03:00) Welcome Note Collin Ewald(04:25) Longevity Highlights in 2022 in the Ewald Lab, ETH Zurich(07:08) Published Results of a 9 year study to understand the mTOR Kinase and its role in ageing better(08:52) Longevity Research and Horizon Europe(11:08) How to Bridge the Gap in Horizon PrograThe Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link
#102: Uncover the Hidden Strategies for Securing Funding and Achieving Impact in European Research
Jan 16 2023
#102: Uncover the Hidden Strategies for Securing Funding and Achieving Impact in European Research
Are you ready to unlock the secrets of securing funding and achieving impact in the world of European research and innovation? In this episode of our podcast, we explore the latest trends and developments in research and innovation with Kimberly Cornfield, Assistant Director (Project Development & Management) and Head of European Research and Innovation at University College London (UCL). UCL is one of the top-performing universities under the EU's Horizon 2020 program and has secured around €400 million over the last seven years to support its research and innovation activities.Kimberly and her team connect scientists and businesses around EU collaborative funding opportunities and offer a suite of support services to improve the chances of success in obtaining funding and achieving impact objectives. We'll discuss the current state of European research funding, the challenges and benefits of virtual meetings, and the future for research and innovation.💡 LINKS TO MORE CONTENT.If you like the episode, become a subscriber and support the show: https://lsg2g.substack.com/subscribePodcast Episodes: https://pod.link/1493847125Please support this show by checking out the companies that make it possible: https://linktr.ee/lsg2Watch on YoutubeKimberly CornfieldChristian Soschner⏰  Timestamps:(00:00) Introduction Kimberly Cornfield, UCL, and Horizon Europe(05:12) Highlights UCL and Horizon Europe Grant Funding in 2022(07:20) Advantages and Challenges – Virtual or Real Life Meetings?(09:00) Benefits of the Virtual World for UCL Research Projects(10:21) Horizon Europe(14:28) Future Trends in Research(17:28) The Rise of Social Sciences(19:28) The Relevance of Fairy Tales for Research(23:05) The Horizon Europe Work Programme for 2023(26:00) Wishes for 2023The Physician Syndicate: Angel Investing | Venture Capital | Startups | Personal FinanceThe Physician Syndicate Podcast: A podcast for physicians to jump into the startup world. Listen on: Apple Podcasts   SpotifySupport the showDo you want to support the podcast team? Join the LSG2G Newsletter as a paying member: Link